Powerful silylation reagent useful in GC and GC-MS for the derivatization of a wide range of functional groups under mild conditions, similar to N,O-Bis(trimethyl-silyl)-acetamide, with the advantage that both the reagent and its by-product, trifluoroacetamide, are more volatile than the corresponding non-fluorinated analogues: Biochem. Biophys. Res. Commun., 31, 616 (1968).