Efficient peptide coupling agent for N-methylated amino esters for which coupling with a number of conventional reagents has proved ineffective or slow, and giving superior results to 1H-Benzotriazol-1-yl-oxytri(1-pyrrolidinyl)-phosphonium hexafluorophosphate, in this type of reaction: J. Org. Chem., 59, 2437 (1994).
Can also be used to activate formamides, e.g. reaction of DMF with primary amines to yield formamidines: Tetrahedron Lett., 40, 5487 (1999).